Table 1

Aetiology and associated risk factors for development of SIBO

Gut dysmotilityAltered GI secretionsAnatomical alterationsImpaired immunity
Diabetes mellitusMedications—proton pump inhibitorsRoux-en-Y gastric bypassHypogammaglobulinaemia
Connective tissue disorders for example, systemic sclerosis, Ehlers DanlosChronic pancreatitisStrictures, adhesions, fistulae (Crohn’s)Combined variable immunodeficiency
Visceral neuropathies and myopathiesChronic liver diseaseIleocecal valve impairment /resection
Medications—opioids, anticholinergics Small bowel diverticular disease
Parkinson’s disease
Radiation enteropathy
  • GI, gastrointestinal; SIBO, small intestinal bacterial overgrowth.