Characteristics of those with and without symptoms compatible with Rome IV FD
| Symptoms not compatible with FD (n=166, 43%) | Symptoms compatible with FD (n=221, 57%) | P value | |
| Demographics | |||
| Mean age, years (SD) | 61 (17) | 58 (17) | 0.15 |
| White race | 149 (90) | 195 (88) | 0.28 |
| Female | 77 (46) | 136 (62) | 0.003 |
| Body mass index (SD) | 27 (6) | 28 (6) | 0.35 |
| Past medical history | |||
| Cholecystectomy | 10 (6) | 25 (11) | 0.07 |
| Appendectomy | 26 (16) | 33 (15) | 0.84 |
| Fibromyalgia | 4 (2) | 21 (10) | 0.005 |
| Chronic fatigue syndrome | 6 (4) | 34 (15) | <0.001 |
| Alarm features | |||
| Age ≥55 years | 118 (71) | 145 (66) | 0.25 |
| Dysphagia | 42 (25) | 73 (33) | 0.10 |
| Unintentional weight loss | 21 (13) | 54 (24) | 0.004 |
| Anaemia | 38 (23) | 32 (15) | 0.03 |
| Vomiting blood | 3 (2) | 8 (4) | 0.29 |
| Family history of upper GI cancer | 14 (8) | 17 (8) | 0.79 |
| Any of the above alarm features | 137 (83) | 186 (84) | 0.67 |
| Psychological distress and somatisation | |||
| Anxiety (%, HADS score≥11) | 32 (19) | 82 (37) | <0.001 |
| Depression (%, HADS score≥11) | 19 (11) | 60 (27) | <0.001 |
| Total HADS score (SD) | 11.2 (8.2) | 16.6 (9.0) | <0.001 |
| Total PHQ-12 score (SD) | 5.9 (3.6) | 9.3 (4.3) | <0.001 |
| Clinically significant endoscopy findings | |||
| Upper GI cancer | 2 (1) | 3 (1) | 0.63 |
| Barrett’s oesophagus | 8 (5) | 7 (3) | 0.41 |
| Grade C/D oesophagitis | 1 (0.6) | 2 (1) | 0.61 |
| Strictures | 3 (2) | 4 (2) | 0.65 |
| Peptic ulcer disease | 4 (2) | 5 (2) | 0.59 |
| Any of the above | 17 (10) | 20 (9) | 0.69 |
FD, functional dyspepsia; GI, gastrointestinal; HADS, Hospital Anxiety and Depression Score; PHQ-12, Patient Health Questionnaire-12.