Clinical studySuperiority of the serum-ascites albumin difference over the ascites total protein concentration in separation of “transudative” and “exudative” ascites☆
References (12)
- et al.
Serum-ascites albumin concentration gradient: a physiological approach to the differential diagnosis of ascites
Gastroenterology
(1983) - et al.
Diagnostic value of ascitic fluid lactic dehydrogenase, protein and WBC levels
Arch Intern Med
(1978) - et al.
The chemistry and cytology of serous fluids
J Lab Clin Med
(1929) - et al.
Observations on the chemical and physical relation between blood serum and body fluids. I. The nature of edema fluids and evidence regarding the mechanism of edema formation
J Clin Invest
(1934) The diagnostic significance of serous fluids in disease
N Engl J Med
(1940)- et al.
The value of examination of ascitic fluid and blood for lipids and for proteins by electrophoresis
Gastroenterology
(1958)
Cited by (106)
Pleural Fluid Analysis: Are Light's Criteria Still Relevant After Half a Century?
2021, Clinics in Chest MedicineCitation Excerpt :In 1981, Hoefs30 described for the first time a good correlation between portal vein pressure and the calculation of the serum to ascites albumin gradient. It soon became apparent that a serum-ascites albumin difference greater than 1.1 g/dL offered better discrimination of the causes of ascites because it suggested the presence of portal hypertension not only in patients with a transudate type of ascites but also in cases of high protein concentration.31 In a large prospective series of 901 ascites samples from 330 patients, an albumin gradient greater than 1.1 g/dL accurately identified portal hypertension 96.7% of the time, whereas the ascites fluid total protein concentration did so only 55.6% of the time.32
Ascites and Hyponatremia
2017, Zakim and Boyer's Hepatology: A Textbook of Liver DiseaseDifferentiation of exudate from transudate ascites based on the dipstick values of protein, glucose, and pH
2013, American Journal of Emergency MedicineCitation Excerpt :Several studies have been performed for differentiating the ascitic fluid as either exudate or transudate. The serum-ascites albumin gradient (SAAG) has been proved superior to other parameters in categorizing ascites in several studies [2,5–9]. However, laboratory assessing of ascitic fluid and serum is not always available in some small outpatient setting, and sometimes, it cannot be done as in emergency basis.
Ascites
2012, Zakim and Boyer's HepatologyAscites
2006, Zakim and Boyer's HepatologyDifferential diagnosis of ascites: Etiologies, ascitic fluid analysis, diagnostic algorithm
2023, Clinical Chemistry and Laboratory Medicine
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This work was supported by the Hastings Foundation, Los Angeles, California. Reprints not available.
- 1
From the Division of Hepatology, Department of Medicine, University of Southern California School of Medicine, Los Angeles, California, and the Liver Unit, Rancho Los Amigos Hospital, Downey, California.