Original ArticleDoes prophylactic pancreatic stent placement reduce the risk of post-ERCP acute pancreatitis? A meta-analysis of controlled trials
Section snippets
Materials and methods
Systematic methods were used to identify all relevant studies, to assess studies for eligibility, to describe variations in study design and execution, and to evaluate study quality.12
Study identification and selection
The search identified 26 potentially relevant studies. After scanning titles and abstracts, 18 studies were excluded. Studies that were excluded either did not have a control group, included patients with chronic pancreatitis, or compared pancreaticobiliary sphincterotomy vs. biliary sphincterotomy alone. Five studies published in peer-reviewed journals and 3 abstracts were retained for further evaluation.7., 8., 9., 10., 11., 17., 18., 19. One article was excluded because of retrospective data
Discussion
This meta-analysis shows that prophylactic pancreatic stent placement reduces the rate of post-ERCP acute pancreatitis in patients at high risk for this complication. There was a significant reduction in the frequency of mild acute pancreatitis and a trend toward reduction in severe acute pancreatitis. Pancreatic stent placement had a low complication rate and a high success rate (>88%), which suggests that it is technically safe and not difficult in experienced hands.
Acute pancreatitis is the
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Amitabh Chak is supported by a Midcareer Investigator Award in Patient Oriented Research from the National Institute of Health.