Original ArticleA randomized single-blind trial of split-dose PEG-electrolyte solution without dietary restriction compared with whole dose PEG-electrolyte solution with dietary restriction for colonoscopy preparation
Section snippets
Patients
Patients seen in the ambulatory outpatient clinic of the American University of Beirut Medical Center who required elective colonoscopies were enrolled in this study. Exclusion criteria included patients under 18 years of age, the presence of a severe illness (cardiac, renal, or metabolic), active alcoholism, drug addiction, major psychiatric illness, known allergies to PEG, or refusal to consent to the study. The study was conducted at the American University of Beirut Medical Center between
Results
A total of 141 patients were approached, recruited, and randomized into Group A (73 patients) or Group B (68 patients). None of the patients declined, dropped out, or were excluded for any reason. Recruitment did not involve consecutive patients because of scheduling purposes (study patients had to be scheduled as of 9:00 AM). There were 80 men and 61 women, with a mean age of 57 ± 14 years (range 20-84 years). Patient demographics and indications for colonoscopy are listed in Table 2.
The
Discussion
Colonoscopy remains the most preferred procedure for diagnosing colonic and terminal ileal disease. A successful procedure requires an adequate bowel preparation. The currently used bowel-cleansing solutions dictate the rapid ingestion of large amounts of unpalatable fluids, as well as adherence to a liquid diet. These regimens overburden patients and justify the commonly used statement that “the preparation is worse than the procedure.” Many studies have tackled these concerns by trying to
References (20)
- et al.
Development of a lavage solution associated with minimal water and electrolyte absorption or secretion
Gastroenterology
(1980) - et al.
Sodium phosphate preparation for colonoscopy: onset and duration of bowel activity
Gastrointest Endosc
(1999) - et al.
Meta-analysis and cost comparison of polyethylene glycol lavage versus sodium phosphate for colonoscopy preparation
Gastrointest Endosc
(1998) - et al.
Oral sodium phosphate versus sulfate-free polyethylene glycol electrolyte lavage solution in outpatient preparation for colonoscopy: a prospective comparison
Gastrointest Endosc
(1996) - et al.
Single-day, divided-dose oral sodium phosphate laxative versus intestinal lavage as preparation for colonoscopy: efficacy and patient tolerance
Gastrointest Endosc
(1995) - et al.
A randomized single-blind trial of whole versus split-dose polyethylene glycol-electrolyte solution for colonoscopy preparation
Gastrointest Endosc
(2003) - et al.
Drinking before endoscopy: milk or water?
Gastrointest Endosc
(1997) - et al.
Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation
Gastrointest Endosc
(1998) - et al.
Effect of oral sodium phosphate colon preparation on serum electrolytes in patients with normal serum creatinine
Gastrointest Endosc
(1996) - et al.
Colonic mucosal abnormalities associated with oral sodium phosphate solution
Gastrointest Endosc
(1996)
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2018, Digestive and Liver DiseaseCitation Excerpt :There are few certainties as to the diet to be adopted before colonoscopy [31–35]. Two very recent meta-analyses showed that a low-fibre diet provides a preparation quality that is non-inferior to a clear liquid diet and is associated with better tolerability and compliance [35–40]. There is no clear evidence in the literature that prolonging dietary restrictions for more than one day before colonoscopy improves the quality of bowel preparation.
The association among diet, dietary fiber, and bowel preparation at colonoscopy
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See CME section; p. 275.