Original article—alimentary tractAn Association Between Microscopic Colitis and Celiac Disease
Section snippets
Subjects
Patients were selected from an anonymized database of 1009 patients with celiac disease who attended the Celiac Disease Center at Columbia University in New York, a tertiary referral center. The majority of patients seen come from the metropolitan area of New York City. In addition the majority are self-referred (70%). All patients are prospectively entered into the database after giving informed consent about the database. To be included in this study, adult patients were required to have
Results
Four percent (n = 44) of the patients in our cohort had microscopic colitis, 33 lymphocytic colitis, and 11 collagenous colitis. All cases were diagnosed after 1990. Subsequent to this time point these 44 cases represented 5.1% of the cohort. The annual incidence is shown in Figure 1. As shown in Table 1, the mean age of diagnosis of celiac disease in those with microscopic colitis was significantly greater than those without microscopic colitis (P < .0001). There was no difference in the
Discussion
Our study illustrates that microscopic colitis occurred in 4.3% of a large cohort seen in a tertiary celiac disease center. All cases were diagnosed after 1990, coincident with publications about the entity in the literature appearing in the 1980s.7, 8, 20, 21, 22, 23, 24, 25, 26 The occurrence of microscopic colitis in 4.3% of our celiac cohort, however, represents a markedly increased rate of occurrence of microscopic colitis compared with a general, population based study from Olmsted
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Conflict of interest The authors disclose no conflicts.