Original articleSystematic reviews and meta-analysesNo Evidence for Efficacy of Radiofrequency Ablation for Treatment of Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis
Section snippets
Selection Criteria
Any randomized controlled trial evaluating the efficacy of the Stretta procedure compared with sham or medical treatment for the management of GERD patients requiring PPIs regardless of publication status (eg, abstracts, unpublished studies, and so forth) was eligible for inclusion in the systematic review. Studies that were not a randomized controlled trial or did not have a control or included specialized treatment groups such as postreflux surgery or obese patients were excluded. There was
Studies
The initial electronic search retrieved 136 references that were screened by title and abstract (Figure 1). Of those, 31 references were selected for full-text review. After the final screening, 4 published studies met the predetermined inclusion criteria. No abstracts or unpublished studies met our inclusion criteria.
The study by Arts et al16 was a single-center, randomized, controlled trial comparing Stretta with sham therapy in 22 patients (11 in each group). Patients underwent 2 upper
Discussion
We performed a systematic review performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards.17 The overall quality of evidence from randomized controlled trials on the efficacy of the Stretta procedure is very low.15, 16, 25, 26 It may be plausible that the low-quality evidence may be an artifact of reporting and not necessarily conduct. However, the choice of not including clinically relevant outcomes (ie, normalization of % total pH < 4 over 24 h)
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Conflicts of interest Joel E. Richter is consultant for Endostim, Inc and Givens Imaging.