Original articleAlimentary tractDevelopment and Validation of a Scoring System to Identify Patients With Microscopic Colitis
Section snippets
Participants and Setting
The study was conducted among individuals with chronic diarrhea referred for colonoscopy at the endoscopy units in Leeds Teaching Hospitals National Health Service Trust, West Yorkshire during a 2-year period between 2011 and 2012. There are 3 endoscopy units at Leeds General Infirmary, St James’s University Hospital, and Wharfedale General Hospital, which are staffed by the same team and follow identical clinical protocols. The hospitals provide secondary care services to a local population of
Derivation Cohort
In total, 476 of 2151 patients (22.1%) with chronic diarrhea undergoing complete colonoscopy with random colonic biopsies from 2011 were included in the derivation cohort. The mean age of these individuals was 53.6 years (range, 17–91 years), and 303 (63.7%) were female. Of the included subjects, 85 patients (17.9%) were diagnosed with MC on histologic grounds, 67 with collagenous colitis and 18 with lymphocytic colitis. The remaining 391 patients had a macroscopically normal colonoscopy and
Discussion
This study was designed to derive and validate a novel diagnostic scoring system to distinguish patients with MC from those with functional bowel disease on the basis of clinical data, which can easily be collected and implemented when taking a history from the patient. In our derivation cohort, factors associated with MC included female gender, age 50 years and older, NSAID or PPI use, presence of weight loss, and absence of abdominal pain. When these were combined in our diagnostic scoring
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2019, Digestive and Liver DiseaseCitation Excerpt :The results of the present study confirm the predictive value of patients’ age. In fact, an age of 50 or 55 years or more was a predictive variable of MC in previous studies [7–9]. In our study, a cut-off of 60 years old or more was a risk factor for MC.
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Conflicts of interest The authors disclose no conflicts.