Original ArticleClinical EndoscopyHistopathologic correlates of noncalcific chronic pancreatitis by EUS: a prospective tissue characterization study
Section snippets
Patients and methods
This was a prospective study of consecutive patients referred for evaluation of pancreaticobiliary complaints who underwent subsequent pancreatic surgery over a 15-month period, from June 2004 to September 2005. All patients with pancreatic lesions that were potentially operable by EUS were eligible for inclusion in this study. Exclusion criteria were (1) inadequate visualization of the pancreas; (2) refusal to undergo surgery; (3) poor surgical candidates; (4) patients who required
Results
Of 82 eligible patients who underwent EUS over a 12-month period, 40 were excluded because of metastatic or locally advanced disease at CT in 12 patients, locally advanced disease diagnosed at EUS (11), poor surgical candidates (5), preoperative chemoradiation (3), advanced disease diagnosed at surgery (3), poor visualization of the pancreas at EUS (1), calcific pancreatitis by CT/ERCP (2), and refusal to undergo surgery (3). Of the 42 patients who underwent pancreatic resection (Whipple
Discussion
The results of this prospective study support the concept that EUS CP changes correlate with histologic NCCP.
Studies on CP by using a histologic criterion standard are desirable but have remained impractical for obvious ethical considerations. Hence, CP, in general, is diagnosed based on imaging or function testing. ERCP and secretin stimulation test are regarded as the criterion standard for imaging and for function testing, respectively.15 Contrary to ERCP, EUS has a very low risk of
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