Journal of the American Medical Directors Association
Original StudyDefining Sarcopenia in Terms of Incident Adverse Outcomes
Section snippets
Participants
A total of 4000 community-living Chinese men and women aged 65 and older were recruited for a cohort study on osteoporosis and general health (Mr Os) in Hong Kong between August 2001 and February 2003 by placing recruitment notices in community centers for older adults and housing estates. The aim was to recruit a stratified sample so that approximately 33% each would be aged 65 to 69, 70 to 74, and 75 and older. Those who were unable to walk independently, had had bilateral hip replacement, or
Results
Tables 2 and 3 show the baseline characteristics of participants according to sarcopenia diagnosis using the 2 FNIH definitions. Using the first definition, men who had sarcopenia were older; less educated; and had higher prevalence of COPD, cognitive impairment, and depressive symptoms; and 5 kg or more weight loss from age 25. For women, fewer differences were observed. Women classified as having sarcopenia were older and more had cognitive impairment and depressive symptoms. When slow gait
Discussion
The results show that sarcopenia FNIH diagnosis among Caucasians using cutoff values that have been derived from prospective studies involving a large number of participants26 does not appear to have any great advantage over definitions from consensus panels or the screening tool, when applied to a Chinese population. Some definitions have higher odds ratio (OR) in predicting some adverse outcomes compared with others, but there is no consistent pattern. For example, the highest OR for
Conclusion
When applied to a Chinese elderly population, criteria used for diagnosis of sarcopenia derived from European, Asian, and international consensus panels, from US cutoff values defined from incident physical limitation, and the SARC-F screening tool, all have similar performance in predicting incident physical limitation and mortality.
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The authors declare no conflicts of interest.