Abstract
In a double-blind, crossover study, wedetermined whether microencapusulated pancreatic enzymesreduce postprandial symptoms experienced by healthyvolunteers after ingestion of a high calorie, high fat meal. At 7 AM, 18 subjects ingested 185 g ofcookies (1196 calories and 72 g of fat) with threepancrelipase capsules or a placebo. The severity ofgastrointestinal symptoms and flatus passages wererecorded for 15-17 hr, and end-alveolar samples wereobtained hourly for 10 hr. Ingestion of pancreaticsupplements was associated with a significant (P =0.049) reduction in bloating over the entire recordingperiod, and with significant reductions in bloating,gas, and fullness during the dinner to bedtime period.Pancreatic supplements had no significant effect onbreath H2 or CH4 concentration.The finding that pancreatic supplements reduce postprandial symptoms inhealthy subjects suggests that these supplements alsomight be beneficial in irritable bowelsyndrome.
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Suarez, F., Levitt, M.D., Adshead, J. et al. Pancreatic Supplements Reduce Symptomatic Response of Healthy Subjects to a High Fat Meal. Dig Dis Sci 44, 1317–1321 (1999). https://doi.org/10.1023/A:1026675012864
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DOI: https://doi.org/10.1023/A:1026675012864