Clinical–liver, pancreas, and biliary tractAssociation of Cardiorespiratory Fitness, Body Mass Index, and Waist Circumference to Nonalcoholic Fatty Liver Disease
Section snippets
Patient Data
The Aerobics Center Longitudinal Study is an epidemiologic investigation of patients who received a thorough medical examination at the Cooper Clinic in Dallas, Texas. Data collection for the Aerobics Center Longitudinal Study began in 1970, and to date there are more than 70,000 study participants in the database.16, 17, 18 Most of the participants are non-Hispanic whites, residents of the United States, and are well educated. Participants for this analysis are derived from a previously
Results
Table 1 presents the characteristics of the participants by the absence (n = 194) and presence of NAFLD (n = 24, 11.0%). Similar in age, participants with NAFLD were heavier, had more central adiposity, were less fit, and had worse cardiovascular risk factor profiles compared with participants without NAFLD. For example, almost 92% of individuals with NAFLD had metabolic syndrome compared with 30.9% of individuals without NAFLD (P < .001). There was no difference in alcoholic drinks consumed
Discussion
The primary finding of this cross-sectional study was a lower prevalence of NAFLD across higher levels of cardiorespiratory fitness and a higher prevalence of NAFLD across higher levels of BMI and waist circumference. When examined within the same model we found fitness level (inversely) and BMI category (directly) both to be associated significantly with the prevalence of NAFLD. However, both the fitness–NAFLD and BMI–NAFLD relationships were attenuated when central adiposity, in particular
Conclusion
Fitness (inversely) and BMI (directly) were associated with the prevalence of NAFLD. However, these associations were attenuated when abdominal obesity was included in the statistical model. There is a need for future work examining the role of weight loss and physical activity in the prevention and treatment of NAFLD.
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Supported in part by U.S. Public Health Service research grant AG06945 from the National Institute on Aging, and grant HL62508 from the National Heart, Lung, and Blood Institute.