Original ResearchClinical—LiverFrequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States
Section snippets
Study Population
The study cohort included 35,781 adult patients (18 years of age or older) who underwent a liver transplant in the United States from January 1, 2001, to December 31, 2009. Each patient is only represented once in the cohort; thus, a second transplant during the study period was not included. Demographic, laboratory, radiologic, clinical, and surgical information was analyzed. Clinical data obtained at the time of transplant included age at transplant, sex, age, ethnicity, primary liver
Results
A total of 35,781 patients underwent a primary liver transplant from 2001 to 2009. NASH was documented as the primary or secondary indication for 1959 liver transplant recipients over the study period.
Discussion
Although the prevalences of NAFLD and NASH are quite well known, the frequency with which NASH results in cirrhosis with decompensation has been difficult to ascertain. One indication of the importance of NASH as a cause of end-stage liver disease is the frequency of NASH as an indication for liver transplantation, currently and over the course of time. The most important findings of this study are that NASH is the third most common indication for liver transplantation in the United States and
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This article has an accompanying continuing education activity on page e22. Learning Objective: Upon completion of this CME exercise, successful learners will be able to review the comparative frequency, associations and outcomes of liver transplantation for NASH.
Conflicts of interest The authors disclose no conflicts.
Funding Supported by Public Health Service grant NIDDK R01 DK069757-01 and GCRC RR00585.