Original ResearchFull Report: Basic and Translational—Alimentary TractPouch Inflammation Is Associated With a Decrease in Specific Bacterial Taxa
Section snippets
Patients and Controls
Pouch patients were recruited at the Comprehensive Pouch Clinic of the Tel Aviv Medical Center, a tertiary referral center for IBD and the national referral center for pouch patients. Both an IBD-oriented gastroenterologist (I.D.) and a colorectal surgeon (H.T.) routinely examine all patients. Study inclusion criteria included confirmed precolectomy diagnosis of UC (based on clinical, endoscopic, histologic, and imaging criteria), a minimum of 12 months follow-up after ileostomy closure, and at
Results
A total of 140 pouch patients (131 UC and 9 FAP) were recruited and followed-up during a period of 18 months (Table 1). The UC pouch patients included 38 with a normal pouch, 46 with acute or recurrent-acute pouchitis, 37 with chronic pouchitis/CLDP, and 10 whose classification changed during the study. For the major part of this study, only samples obtained from patients who had not been exposed to antibiotics in the month preceding sample procurement were used (antibiotic-free patients, n =
Discussion
Microbial dysbiosis is a term widely used to describe imbalances in gut microbiota associated with disease. Reductions in bacterial diversity and in the genus Faecalibacterium are the hallmarks of dysbiosis in IBD. In addition, a reduction in Bacteroides and in multiple taxa of the Lachnospiraceae and Ruminococcaceae had been described in ileal CD, but not in UC. In this study, we focused on UC patients after pouch surgery, specifically on the comparison between those developing pouch
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Medical management of chronic pouch inflammation
2022, Current Research in Pharmacology and Drug DiscoveryAGA Technical Review on the Role of Probiotics in the Management of Gastrointestinal Disorders
2020, GastroenterologyCitation Excerpt :Acute, relapsing, or chronic pouchitis is the most common post-surgical complication, occurring in more than one-half of patients.98 Although the etiology of pouchitis is poorly understood, gut microbiota have been suggested to play a role, based on altered fecal microbial communities that associate with disease activity,99 the use of antibiotics as the mainstay of pouchitis therapy,100 and the possible therapeutic role of fecal microbiota transplantation.101 Of the 13 studies included in a comprehensive 2015 Cochrane review102 of multiple different therapies for the treatment and prevention of pouchitis among adults with IPAA for ulcerative colitis, 6 studies103–108 tested probiotics and were included in this technical review; these studies analyzed a total of 176 patients (probiotics, n = 93; placebo, n = 83).
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2020, GastroenterologyGut bacteriome in inflammatory bowel disease: An update on recent advances
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Conflicts of interest The authors disclose no conflicts.
Funding This study was partially supported by a generous grant from the Leona M. and Harry B. Helmsley Charitable Trust.
Author names in bold designate shared co-first authorship.
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Authors share co-first authorship.