Preliminary results of a phase I/II study of sodium pentosanpolysulfate in the treatment of chronic radiation-induced proctitis

Am J Clin Oncol. 1990 Feb;13(1):28-31. doi: 10.1097/00000421-199002000-00008.

Abstract

This is a report of a phase I/II study of 13 patients treated with sodium pentosanpolysulfate (PPS) for chronic radiation-induced proctitis. A complete response was obtained in 82%, a partial response occurred in 9%, and 9% failed to respond to therapy. No significant toxicity was observed. It is concluded that PPS is an effective treatment for chronic radiation-induced proctitis and a phase III randomized, double-blind study of PPS versus placebo is planned.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Drug Evaluation
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Pentosan Sulfuric Polyester / administration & dosage
  • Pentosan Sulfuric Polyester / therapeutic use*
  • Polysaccharides / therapeutic use*
  • Proctitis / drug therapy*
  • Proctitis / etiology
  • Radiation Injuries / drug therapy*
  • Radiation Injuries / etiology
  • Radiotherapy / adverse effects*
  • Rectum / radiation effects
  • Recurrence
  • Remission Induction

Substances

  • Polysaccharides
  • Pentosan Sulfuric Polyester