Health related quality of life in people with advanced chronic liver disease

James G Orr; Tara Homer; Laura Ternent; Julia Newton; Calum J McNeil; Mark Hudson; David E J Jones

doi:10.1016/j.jhep.2014.06.034

Health related quality of life in people with advanced chronic liver disease

J Hepatol. 2014 Nov;61(5):1158-65. doi: 10.1016/j.jhep.2014.06.034. Epub 2014 Jul 7.

Authors

James G Orr¹, Tara Homer², Laura Ternent², Julia Newton¹, Calum J McNeil¹, Mark Hudson¹, David E J Jones³

Affiliations

¹ Institute of Cellular Medicine, Newcastle University, UK.
² Institute of Health and Society, Newcastle University, UK.
³ Institute of Cellular Medicine, Newcastle University, UK. Electronic address: david.jones@newcastle.ac.uk.

PMID: 25010259
DOI: 10.1016/j.jhep.2014.06.034

Abstract

Cirrhosis has a long natural history with considerable symptomatic impacts, particularly in advancing disease. Measuring health related quality of life (HRQOL) in liver disease provides detail about the nature and extent of its effects on individuals. Understanding the drivers of impaired HRQOL can help identify targets for improvement through new treatments or health systems service delivery. Evaluation of novel therapies which target symptomatic improvement, should be done with suitable outcome measures, including HRQOL assessment. In this article, we provide an overview of HRQOL in advanced liver disease for the clinician. A clear description of the important HRQOL tools is given alongside a discussion of the factors, which are known to contribute to impaired HRQOL in advanced liver disease.

Keywords: Cirrhosis; Health related quality of life; Liver; Quality of life.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Ascites
Chronic Disease
Hepatic Encephalopathy
Humans
Liver Cirrhosis
Liver Diseases* / etiology
Quality of Life*
Severity of Illness Index
Surveys and Questionnaires

Abstract

Publication types

MeSH terms

Grants and funding