Contribution of Alcoholic and Nonalcoholic Fatty Liver Disease to the Burden of Liver-Related Morbidity and Mortality

Gastroenterology. 2016 Jun;150(8):1778-85. doi: 10.1053/j.gastro.2016.03.005. Epub 2016 Mar 12.

Abstract

Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are common causes of chronic liver disease. NAFLD is associated with obesity and metabolic syndrome whereas ALD is associated with excessive alcohol consumption. Both diseases can progress to cirrhosis, hepatocellular carcinoma, and liver-related death. A higher proportion of patients with NAFLD die from cardiovascular disorders than patients with ALD, whereas a higher proportion of patients with ALD die from liver disease. NAFLD and ALD each are associated with significant morbidity, impairment to health-related quality of life, and economic costs to society.

Keywords: ALD; Mortality; NAFLD.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Hepatocellular / etiology
  • Carcinoma, Hepatocellular / mortality
  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / mortality
  • Cause of Death
  • Cost of Illness
  • Fatty Liver, Alcoholic / complications
  • Fatty Liver, Alcoholic / mortality*
  • Female
  • Humans
  • Liver Cirrhosis / etiology
  • Liver Cirrhosis / mortality*
  • Liver Neoplasms / etiology
  • Liver Neoplasms / mortality
  • Male
  • Middle Aged
  • Morbidity
  • Non-alcoholic Fatty Liver Disease / complications
  • Non-alcoholic Fatty Liver Disease / mortality*
  • Obesity / complications
  • Obesity / mortality
  • Prevalence
  • Quality of Life