The fundamental pathological process behind ulcerative colitis and Crohn's disease is
intestinal inflammation. As the precise cause of this is not yet completely understood, current …

Calprotectin is a calcium and zinc binding protein of the S100 family derived predominantly
from neutrophils and monocytes. It is detectable in body fluids and tissue samples and is …

Background Gastro‐oesophageal reflux disease affects approximately 20% of western
populations. Barrett's oesophagus, associated with severe gastro‐oesophageal reflux …

The mechanisms by which the lifestyle risk factors obesity, physical inactivity, and low fiber
intake predispose to colorectal cancer (CRC) are unclear. Chronic bowel inflammation …

Background & Aims Swallowed topical-acting corticosteroids are recommended as first-line
therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized for …

Background Patients presenting to gastroenterology clinics with symptoms suggestive of
lower-bowel disorders often require extensive investigation to differentiate functional from …

A direct comparison with faecal occult blood has revealed that faecal calprotectin is more
sensitive but less specific for the detection of colorectal neoplasia [3]. However, before …

Background Over 250 000 people in the UK are affected with inflammatory bowel disease
(IBD) and approximately 10 000 new cases are diagnosed every year. These chronic bowel …

There is currently no gold standard test for the diagnosis of inflammatory bowel disease
(IBD). Physicians must rely on a number of diagnostic tools including clinical and …

Although COVID-19 was first recognised as an acute respiratory illness, extra-pulmonary
manifestations are increasingly being recognised. Acute gastrointestinal side effects have …