Next generation diagnostic modalities in gastroenterology–gas phase volatile compound biomarker detection

…, JA Covington, C Harmston… - Alimentary …, 2014 - Wiley Online Library
Background The detection of airborne gas phase biomarkers that emanate from biological
samples like urine, breath and faeces may herald a new age of non‐invasive diagnostics …

HIV and noncommunicable disease comorbidities in the era of antiretroviral therapy: a vital agenda for research in low-and middle-income country settings

…, NP Anand, LM Kline, C Harmston… - JAIDS Journal of …, 2014 - journals.lww.com
In this special 2014 issue of JAIDS, international investigator teams review a host of
noncommunicable diseases (NCDs) that are often reported among people living and aging …

Discovery and characterization of a unique mycobacterial heme acquisition system

MV Tullius, CA Harmston, CP Owens… - Proceedings of the …, 2011 - National Acad Sciences
Mycobacterium tuberculosis must import iron from its host for survival, and its siderophore-
dependent iron acquisition pathways are well established. Here we demonstrate a newly …

[HTML][HTML] Detection of colorectal cancer (CRC) by urinary volatile organic compound analysis

…, S Chambers, N O'Connell, C Bailey, C Harmston… - PloS one, 2014 - journals.plos.org
Colorectal cancer (CRC) is a leading cause of cancer related death in Europe and the USA.
There is no universally accepted effective non-invasive screening test for CRC. Guaiac …

Clinical outcomes and effect of delayed intervention in patients with hollow viscus injury due to blunt abdominal trauma: a systematic review

C Harmston, JBM Ward, A Patel - European journal of trauma and …, 2018 - Springer
Introduction Hollow viscus injury (HVI) due to blunt abdominal trauma remains a diagnostic
challenge, often presenting late and results in delayed intervention. Despite several …

Diagnostic accuracy of faecal biomarkers in detecting colorectal cancer and adenoma in symptomatic patients

…, S Wurie, L Burns, C Harmston… - Alimentary …, 2017 - Wiley Online Library
Background The diagnosis of colorectal cancer (CRC) can be difficult as symptoms are
variable with poor specificity. Thus, there is a quest for simple, non‐invasive testing that can …

Utility of faecal calprotectin in inflammatory bowel disease (IBD): what cut-offs should we apply?

…, M Cheung, C Nwokolo, S Smith, C Harmston… - Frontline …, 2015 - fg.bmj.com
Background Faecal calprotectin (FC), a cytosolic protein released by neutrophils (S100
family) in response to inflammation, is a simple, non-invasive test that can be used to …

[HTML][HTML] The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11

CP Owens, N Chim, AB Graves, CA Harmston… - Journal of Biological …, 2013 - ASBMB
Mycobacterium tuberculosis is the causative agent of tuberculosis, which is becoming an
increasingly global public health problem due to the rise of drug-resistant strains. While …

Respiration during snow burial using an artificial air pocket

CK Grissom, MI Radwin, CH Harmston, EL Hirshberg… - Jama, 2000 - jamanetwork.com
ContextAsphyxia is the most common cause of death after avalanche burial. A device that
allows a person to breathe air contained in snow by diverting expired carbon dioxide (CO2) …

Risk stratification of symptomatic patients suspected of colorectal cancer using faecal and urinary markers

…, C Tomkins, B Singh, C Harmston… - Colorectal …, 2018 - Wiley Online Library
Aim Faecal markers, such as the faecal immunochemical test for haemoglobin (FIT) and
faecal calprotectin (FCP), have been increasingly used to exclude colorectal cancer (CRC) …