[HTML][HTML] The mechanisms of pharmacokinetic food-drug interactions–A perspective from the UNGAP group
The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …
Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state
DM Mudie, K Murray, CL Hoad… - Molecular …, 2014 - ACS Publications
The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly
dependent upon the volumes and distribution of gastric and small intestinal water. However …
dependent upon the volumes and distribution of gastric and small intestinal water. However …
[HTML][HTML] In vivo imaging of intragastric gelation and its effect on satiety in humans
CL Hoad, L Marciani, B de Celis Alonso, C Traynor… - The Journal of …, 2004 - Elsevier
Previous studies indicated that physical characteristics of food influence satiety, but the
relative importance of the oral, gastric, and intestinal behaviors of the food is unclear. The …
relative importance of the oral, gastric, and intestinal behaviors of the food is unclear. The …
Colon hypersensitivity to distension, rather than excessive gas production, produces carbohydrate-related symptoms in individuals with irritable bowel syndrome
G Major, S Pritchard, K Murray, JP Alappadan… - Gastroenterology, 2017 - Elsevier
Background & Aims Poorly digested, fermentable carbohydrates may induce symptoms of
irritable bowel syndrome (IBS) via unclear mechanisms. We performed a randomized trial …
irritable bowel syndrome (IBS) via unclear mechanisms. We performed a randomized trial …
Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and …
ABSTRACT BACKGROUND Chronic constipation is a prevalent disorder that affects
patients' quality of life and consumes resources in healthcare systems worldwide. In clinical …
patients' quality of life and consumes resources in healthcare systems worldwide. In clinical …
Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome
BACKGROUND & AIMS: Postprandial symptoms are common in patients with irritable bowel
syndrome with diarrhea (IBS-D) and could be diet related. We studied postprandial changes …
syndrome with diarrhea (IBS-D) and could be diet related. We studied postprandial changes …
Imaging in inflammatory bowel disease: current and future perspectives
N Shaban, CL Hoad, I Naim, M Alshammari… - Frontline …, 2022 - fg.bmj.com
The use of cross-sectional imaging and ultrasonography has long complemented
endoscopic assessment of inflammatory bowel disease (IBD). Clinical symptoms alone are …
endoscopic assessment of inflammatory bowel disease (IBD). Clinical symptoms alone are …
A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histological factors
CL Hoad, N Palaniyappan, P Kaye… - NMR in …, 2015 - Wiley Online Library
Liver biopsy is the standard test for the assessment of fibrosis in liver tissue of patients with
chronic liver disease. Recent studies have used a non‐invasive measure of T1 relaxation …
chronic liver disease. Recent studies have used a non‐invasive measure of T1 relaxation …
[HTML][HTML] A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects
Background & aims Ingestion of poorly digested, fermentable carbohydrates (fermentable
oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating …
oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating …
[HTML][HTML] Effects of bolus and continuous nasogastric feeding on gastric emptying, small bowel water content, superior mesenteric artery blood flow, and plasma …
AH Chowdhury, K Murray, CL Hoad, C Costigan… - 2016 - journals.lww.com
Objective: We aimed to demonstrate the effect of continuous or bolus nasogastric feeding on
gastric emptying, small bowel water content, and splanchnic blood flow measured by …
gastric emptying, small bowel water content, and splanchnic blood flow measured by …