Optogenetic control of the heart is an emergent technology that offers unparalleled spatio-temporal
control of cardiac dynamics via light-sensitive ion pumps and channels (opsins). This …

Cardiac optical mapping utilises fluorescent dyes to directly image the electrical function of
the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has …

The ability to record and analyse electrical behaviour across the heart using optical and
electrode mapping has revolutionised cardiac research. However, wider uptake of these …

Background The collagen receptor glycoprotein VI (GPVI) is an attractive antiplatelet target
due to its critical role in thrombosis but minor involvement in hemostasis. Objective To …

Patients with heart failure often develop cardiac arrhythmias. The mechanisms and interrelations
linking heart failure and arrhythmias are not fully understood. Historically, research into …

Key points A robust cardiac slicing approach was developed for optical mapping of transmural
gradients in transmembrane potential (V m ) and intracellular Ca 2+ transient (CaT) of …

Optical mapping of animal models is a widely used technique in pre-clinical cardiac
research. It has several advantages over other methods, including higher spatial resolution, …

Atrial fibrillation (AF) affects over 1% of the population and is a leading cause of stroke and
heart failure in the elderly. A feared side effect of sodium channel blocker therapy, ventricular …

Activation of cardiac fibroblasts and differentiation to myofibroblasts underlies development
of pathological cardiac fibrosis, leading to arrhythmias and heart failure. Myofibroblasts are …

Background Although atrial fibrillation ablation is increasingly used for rhythm control
therapy, antiarrhythmic drugs (AADs) are commonly used, either alone or in combination with …