Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation
DR Aldridge, EJ Tranah, DL Shawcross - Journal of clinical and …, 2015 - Elsevier
The syndrome we refer to as Hepatic Encephalopathy (HE) was first characterized by a team
of Nobel Prize winning physiologists led by Pavlov and Nencki at the Imperial Institute of …
of Nobel Prize winning physiologists led by Pavlov and Nencki at the Imperial Institute of …
[HTML][HTML] The microbiota in cirrhosis and its role in hepatic decompensation
J Trebicka, J Macnaughtan, B Schnabl… - Journal of …, 2021 - Elsevier
Cirrhosis–the common end-stage of chronic liver disease–is associated with a cascade of
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …
Ammonia and the neutrophil in the pathogenesis of hepatic encephalopathy in cirrhosis
DL Shawcross, SS Shabbir, NJ Taylor, RD Hughes - Hepatology, 2010 - journals.lww.com
Hepatic encephalopathy (HE) constitutes a neuropsychiatric syndrome which remains a
major clinical problem in patients with cirrhosis. In the severest form of HE, cirrhotic patients …
major clinical problem in patients with cirrhosis. In the severest form of HE, cirrhotic patients …
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease
Chronic liver disease due to alcohol-use disorder contributes markedly to the global burden
of disease and mortality,–. Alcoholic hepatitis is a severe and life-threatening form of alcohol …
of disease and mortality,–. Alcoholic hepatitis is a severe and life-threatening form of alcohol …
Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis
BACKGROUND/AIMS: Studies in acute liver failure show correlation between evidence of a
systemic inflammatory response syndrome (SIRS) and progression of hepatic …
systemic inflammatory response syndrome (SIRS) and progression of hepatic …
[HTML][HTML] PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
Background & Aims Acute decompensation (AD) of cirrhosis may present without acute-on-
chronic liver failure (ACLF)(AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure …
chronic liver failure (ACLF)(AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure …
EASL Clinical Practice Guidelines on the management of hepatic encephalopathy
S Montagnese, PE Rautou, M Romero-Gómez… - Journal of …, 2022 - Elsevier
Summary The EASL Clinical Practice Guidelines (CPGs) on the management of hepatic
encephalopathy (HE) present evidence-based answers to a set of relevant questions (where …
encephalopathy (HE) present evidence-based answers to a set of relevant questions (where …
CD14, CD16 and HLA‐DR reliably identifies human monocytes and their subsets in the context of pathologically reduced HLA‐DR expression by CD14hi/CD16neg monocytes: Expansion of CD14hi …
D Abeles, MJ McPhail, D Sowter… - Cytometry Part …, 2012 - Wiley Online Library
Abstract Changes in monocytes and their subsets (CD14hi/CD16neg, CD14hi/CD16pos and
CD14lo/CD16pos) have been described in several diseases. The combination of CD14 …
CD14lo/CD16pos) have been described in several diseases. The combination of CD14 …
Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis
Background & Aims Susceptibility to bacterial infection is a feature of alcohol-related liver
disease. Programmed cell death 1 (PD1), the T-cell immunoglobulin and mucin domain …
disease. Programmed cell death 1 (PD1), the T-cell immunoglobulin and mucin domain …
[PDF][PDF] Endotoxemia produces coma and brain swelling in bile duct ligated rats
G Wright, NA Davies, DL Shawcross, SJ Hodges… - …, 2007 - Wiley Online Library
This study explores the hypothesis that the inflammatory response induced by administration
of lipopolysaccharide (LPS) exacerbates brain edema in cirrhotic rats; and if so whether this …
of lipopolysaccharide (LPS) exacerbates brain edema in cirrhotic rats; and if so whether this …