Novel insights into autoimmune liver diseases provided by genome-wide association studies

GF Mells, A Kaser, TH Karlsen - Journal of autoimmunity, 2013 - Elsevier
Autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing
cholangitis (PSC) are complex disorders, resulting from the interaction of genetic and …

[HTML][HTML] Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study

T Marjot, AM Moon, JA Cook, S Abd-Elsalam… - Journal of …, 2021 - Elsevier
Background & Aims Chronic liver disease (CLD) and cirrhosis are associated with immune
dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes …

[HTML][HTML] FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

T Brevini, M Maes, GJ Webb, BV John, CD Fuchs… - Nature, 2023 - nature.com
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

GF Mells, JAB Floyd, KI Morley, HJ Cordell… - Nature …, 2011 - nature.com
In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have
been identified in recent genome-wide association studies (GWAS). To identify additional …

[PDF][PDF] The UK‐PBC risk scores: derivation and validation of a scoring system for long‐term prediction of end‐stage liver disease in primary biliary cholangitis

M Carbone, SJ Sharp, S Flack, D Paximadas… - …, 2016 - Wiley Online Library
The biochemical response to ursodeoxycholic acid (UDCA)—so‐called “treatment
response”—strongly predicts long‐term outcome in primary biliary cholangitis (PBC) …

Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid

M Carbone, GF Mells, G Pells, MF Dawwas, JL Newton… - Gastroenterology, 2013 - Elsevier
BACKGROUND, & AIMS: Studies of primary biliary cirrhosis (PBC) phenotypes largely have
been performed using small and selected populations. Study size has precluded …

High mortality rates for SARS-CoV-2 infection in patients with pre-existing chronic liver disease and cirrhosis: preliminary results from an international registry

AM Moon, GJ Webb, C Aloman… - Journal of …, 2020 - journal-of-hepatology.eu
[1] Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality
of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet …

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

JZ Liu, MA Almarri, DJ Gaffney, GF Mells, L Jostins… - Nature …, 2012 - nature.com
We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium
and 8,514 UK population controls across 196,524 variants within 186 known autoimmune …

[HTML][HTML] International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

HJ Cordell, Y Han, GF Mells, Y Li… - Nature …, 2015 - nature.com
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective
immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data …

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

SG Ji, BD Juran, S Mucha, T Folseraas, L Jostins… - Nature …, 2017 - nature.com
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct
destruction;∼ 75% of patients have comorbid inflammatory bowel disease (IBD). We …