Novel insights into autoimmune liver diseases provided by genome-wide association studies
GF Mells, A Kaser, TH Karlsen - Journal of autoimmunity, 2013 - Elsevier
Autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing
cholangitis (PSC) are complex disorders, resulting from the interaction of genetic and …
cholangitis (PSC) are complex disorders, resulting from the interaction of genetic and …
[HTML][HTML] Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study
Background & Aims Chronic liver disease (CLD) and cirrhosis are associated with immune
dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes …
dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes …
[HTML][HTML] FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
GF Mells, JAB Floyd, KI Morley, HJ Cordell… - Nature …, 2011 - nature.com
In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have
been identified in recent genome-wide association studies (GWAS). To identify additional …
been identified in recent genome-wide association studies (GWAS). To identify additional …
[PDF][PDF] The UK‐PBC risk scores: derivation and validation of a scoring system for long‐term prediction of end‐stage liver disease in primary biliary cholangitis
The biochemical response to ursodeoxycholic acid (UDCA)—so‐called “treatment
response”—strongly predicts long‐term outcome in primary biliary cholangitis (PBC) …
response”—strongly predicts long‐term outcome in primary biliary cholangitis (PBC) …
Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid
BACKGROUND, & AIMS: Studies of primary biliary cirrhosis (PBC) phenotypes largely have
been performed using small and selected populations. Study size has precluded …
been performed using small and selected populations. Study size has precluded …
High mortality rates for SARS-CoV-2 infection in patients with pre-existing chronic liver disease and cirrhosis: preliminary results from an international registry
[1] Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality
of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet …
of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet …
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis
We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium
and 8,514 UK population controls across 196,524 variants within 186 known autoimmune …
and 8,514 UK population controls across 196,524 variants within 186 known autoimmune …
[HTML][HTML] International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
HJ Cordell, Y Han, GF Mells, Y Li… - Nature …, 2015 - nature.com
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective
immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data …
immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data …
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct
destruction;∼ 75% of patients have comorbid inflammatory bowel disease (IBD). We …
destruction;∼ 75% of patients have comorbid inflammatory bowel disease (IBD). We …