User profiles for "author:John D Ryan"

John D. Ryan

University of Oxford
Verified email at ndm.ox.ac.uk
Cited by 2290

[HTML][HTML] Consensus Statement on the definition and classification of metabolic hyperferritinaemia

L Valenti, E Corradini, LA Adams, E Aigner… - Nature Reviews …, 2023 - nature.com
Hyperferritinaemia is a common laboratory finding that is often associated with metabolic
dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron …

[HTML][HTML] Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection

P Parikh, JD Ryan, EA Tsochatzis - Annals of translational …, 2017 - ncbi.nlm.nih.gov
Chronic hepatitis B virus (HBV) infection is a major cause of liver morbidity and mortality
worldwide. While a proportion of the 250 million individuals chronically infected with HBV …

[HTML][HTML] Non-invasive markers of liver fibrosis: adjuncts or alternatives to liver biopsy?

JL Chin, M Pavlides, A Moolla, JD Ryan - Frontiers in pharmacology, 2016 - frontiersin.org
Liver fibrosis reflects sustained liver injury often from multiple, simultaneous factors. Whilst
the presence of mild fibrosis on biopsy can be a reassuring finding, the identification of …

[HTML][HTML] An international multidisciplinary consensus statement on MAFLD and the risk of CVD

XD Zhou, G Targher, CD Byrne, V Somers… - Hepatology …, 2023 - Springer
Background Fatty liver disease in the absence of excessive alcohol consumption is an
increasingly common condition with a global prevalence of~ 25–30% and is also associated …

Expenditure freeze: the metabolic response of small mammals to cold environments

MM Humphries, S Boutin, DW Thomas, JD Ryan… - Ecology …, 2005 - Wiley Online Library
There is renewed focus on the ecological determinants of animal metabolism and recent
comparative analyses support the physiological expectation that the field metabolic rate …

Hepatic iron is the major determinant of serum ferritin in NAFLD patients

JD Ryan, AE Armitage, JF Cobbold… - Liver …, 2018 - Wiley Online Library
Abstract Background and Aims Elevated serum ferritin is common in NAFLD, and is
associated with more advanced disease and increased mortality. Hyperferritinaemia in …

[HTML][HTML] PYY plays a key role in the resolution of diabetes following bariatric surgery in humans

C Guida, SD Stephen, M Watson, N Dempster… - …, 2019 - thelancet.com
Background Bariatric surgery leads to early and long-lasting remission of type 2 diabetes
(T2D). However, the mechanisms behind this phenomenon remain unclear. Among several …

Suppression of a deletion mutation in the gene encoding essential PBP2b reveals a new lytic transglycosylase involved in peripheral peptidoglycan synthesis in S …

HCT Tsui, JJ Zheng, AN Magallon… - Molecular …, 2016 - Wiley Online Library
In ellipsoid‐shaped ovococcus bacteria, such as the pathogen Streptococcus pneumoniae
(pneumococcus), side‐wall (peripheral) peptidoglycan (PG) synthesis emanates from …

A multidisciplinary approach to the management of NAFLD is associated with improvement in markers of liver and cardio-metabolic health

A Moolla, K Motohashi, T Marjot, A Shard… - Frontline …, 2019 - fg.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is a globally prevalent health problem, associated
in its more severe forms with increased liver-related and cardiovascular-related morbidity …

[PDF][PDF] Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis

JD Ryan, E Ryan, A Fabre, MW Lawless, J Crowe - Hepatology, 2010 - Wiley Online Library
Hereditary hemochromatosis (HH) is a common inherited iron overload disorder. The vast
majority of patients carry the missense Cys282Tyr mutation of the HFE gene. Hepcidin, the …