Lifestyle risk factors for serrated colorectal polyps: a systematic review and meta-analysis

L Bailie, MB Loughrey, HG Coleman - Gastroenterology, 2017 - Elsevier
Background & Aims Certain subsets of colorectal serrated polyps (SP) have malignant
potential. We performed a systematic review and meta-analysis to investigate the …

[HTML][HTML] QuPath: Open source software for digital pathology image analysis

P Bankhead, MB Loughrey, JA Fernández… - Scientific reports, 2017 - nature.com
QuPath is new bioimage analysis software designed to meet the growing need for a user-
friendly, extensible, open-source solution for digital pathology and whole slide image …

Alcohol, smoking and the risk of premalignant and malignant colorectal neoplasms

IO Fagunwa, MB Loughrey, HG Coleman - Best practice & research …, 2017 - Elsevier
Colorectal cancer (CRC) is the third most common cancer worldwide and has a complex
aetiology consisting of environmental and genetic factors. In this review, we evaluate the …

[HTML][HTML] Dataset for pathology reporting of colorectal cancer: recommendations from the International Collaboration on Cancer Reporting (ICCR)

MB Loughrey, F Webster, MJ Arends, I Brown… - Annals of …, 2022 - journals.lww.com
Objective: The aim of this study to describe a new international dataset for pathology
reporting of colorectal cancer surgical specimens, produced under the auspices of the …

[HTML][HTML] Swarm learning for decentralized artificial intelligence in cancer histopathology

OL Saldanha, P Quirke, NP West, JA James… - Nature medicine, 2022 - nature.com
Artificial intelligence (AI) can predict the presence of molecular alterations directly from
routine histopathology slides. However, training robust AI systems requires large datasets …

[PDF][PDF] Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

EG Vazquez, N Nasreddin, GN Valbuena… - Cell Stem Cell, 2022 - cell.com
Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs),
but following injury, dedifferentiation results in the emergence of LGR5− ve regenerative …

[PDF][PDF] Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study

SJ Wagner, D Reisenbüchler, NP West, JM Niehues… - Cancer Cell, 2023 - cell.com
Deep learning (DL) can accelerate the prediction of prognostic biomarkers from routine
pathology slides in colorectal cancer (CRC). However, current approaches rely on …

Challenging the cancer molecular stratification dogma: intratumoral heterogeneity undermines consensus molecular subtypes and potential diagnostic value in …

PD Dunne, DG McArt, CA Bradley, PG O'Reilly… - Clinical Cancer …, 2016 - AACR
Purpose: A number of independent gene expression profiling studies have identified
transcriptional subtypes in colorectal cancer with potential diagnostic utility, culminating in …

British Society of Gastroenterology/Association of Coloproctologists of Great Britain and Ireland guidelines for the management of large non-pedunculated colorectal …

MD Rutter, A Chattree, JA Barbour, S Thomas-Gibson… - Gut, 2015 - gut.bmj.com
These guidelines provide an evidence-based framework for the management of patients
with large non-pedunculated colorectal polyps (LNPCPs), in addition to identifying key …

[HTML][HTML] BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1tumour phenotype

C Snell, M Krypuy, EM Wong… - Breast Cancer …, 2008 - Springer
Introduction Individuals with germline mutations in the BRCA1 gene have an elevated risk of
developing breast cancer, and often display characteristic clinicopathological features. We …