Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders
seen by clinicians in both primary and secondary care. Since publication of the last British …

Background Abdominal pain is a core symptom of IBS and a primary driver of care seeking.
Visceral hypersensitivity is a key pathophysiological mechanism and therapeutic target for …

Functional dyspepsia (FD) is a common disorder of gut–brain interaction, affecting
approximately 7% of individuals in the community, with most patients managed in primary …

Functional gastrointestinal disorders are commonly encountered in clinical practice, and
pain is their commonest presenting symptom. In addition, patients with these disorders often …

Patients diagnosed with hypermobile Ehlers-Danlos syndrome and hypermobile spectrum
disorders are increasingly presenting to secondary and tertiary care centres with …

Although a relationship between emotional state and feeding behavior is known to exist, the
interactions between signaling initiated by stimuli in the gut and exteroceptively generated …

The autonomic nervous system (ANS) integrates afferent and motor activity for homeostatic
processes including pain. The aim of the study was to compare hitherto poorly characterised …

Although recognised as a cause of chronic diarrhoea for over forty years, diagnostic tests
and treatments for bile acid malabsorption (BAM) remain controversial. Recent National …

Background There are minimal epidemiological data comparing the burden of disorders of
gut brain interaction (DGBI) in the UK with other countries. We compared the prevalence of …

Results: In 2009, a mean of 16 (limits of normal variation 4–28) patients were referred for PN
each month. After introduction of the NST, this rose to 26 (10–42) referrals per month. The …