Innate and adaptive immunity in inflammatory bowel disease

A Geremia, P Biancheri, P Allan, GR Corazza… - Autoimmunity …, 2014 - Elsevier
Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC).
The exact cause of IBD remains unknown. Available evidence suggests that an abnormal …

Research gaps in diet and nutrition in inflammatory bowel disease. A topical review by D-ECCO working group [dietitians of ECCO]

R Sigall-Boneh, A Levine, M Lomer… - Journal of Crohn's …, 2017 - academic.oup.com
Although the current doctrine of IBD pathogenesis proposes an interaction between
environmental factors and gut microbiota in genetically susceptible individuals, dietary …

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

R Cooney, J Baker, O Brain, B Danis, T Pichulik… - Nature medicine, 2010 - nature.com
Nucleotide-binding oligomerization domain–containing-2 (NOD2) acts as a bacterial sensor
in dendritic cells (DCs), but it is not clear how bacterial recognition links with antigen …

[HTML][HTML] Intestinal failure: a review

P Allan, S Lal - F1000Research, 2018 - ncbi.nlm.nih.gov
Intestinal failure (IF) is the inability of the gut to absorb necessary water, macronutrients
(carbohydrate, protein, and fat), micronutrients, and electrolytes sufficient to sustain life and …

[PDF][PDF] The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release

O Brain, BMJ Owens, T Pichulik, P Allan, E Khatamzas… - Immunity, 2013 - cell.com
NOD2 is an intracellular sensor that contributes to immune defense and inflammation. Here
we investigated whether NOD2 mediates its effects through control of microRNAs (miRNAs) …

[PDF][PDF] Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets

MEB FitzPatrick, NM Provine, LC Garner, K Powell… - Cell reports, 2021 - cell.com
Tissue-resident memory T (T RM) cells provide key adaptive immune responses in infection,
cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal T RM …

Needs-based quality of life in adults dependent on home parenteral nutrition

ST Burden, DJ Jones, M Gittins, J Ablett, M Taylor… - Clinical nutrition, 2019 - Elsevier
Background & aims Home parenteral nutrition (HPN) provides life sustaining treatment for
people with chronic intestinal failure. Individuals may require HPN for months or years and …

[HTML][HTML] A pilot study on automatic three-dimensional quantification of Barrett's esophagus for risk stratification and therapy monitoring

S Ali, A Bailey, S Ash, M Haghighat, P Allan, T Ambrose… - Gastroenterology, 2021 - Elsevier
Background & Aims Barrett's epithelium measurement using widely accepted Prague C&M
classification is highly operator dependent. We propose a novel methodology for measuring …

Compromised cerebrovascular regulation and cerebral oxygenation in pulmonary arterial hypertension

S Malenfant, P Brassard, M Paquette… - Journal of the …, 2017 - Am Heart Assoc
Background Functional cerebrovascular regulatory mechanisms are important for
maintaining constant cerebral blood flow and oxygen supply in heathy individuals and are …

Intestinal transplantation: a review

L Loo, G Vrakas, S Reddy, P Allan - Current opinion in …, 2017 - journals.lww.com
With advancements in immunosuppressive drugs, induction regimens, standardization of
surgical techniques and improved postoperative care, survival is increasing. In due course, it …