Inflammatory bowel diseases are common, complex, immune-mediated conditions with a
sharply rising global prevalence. While major advances since 2000 have provided strong …

The cumulative impact of chronic inflammation in patients with inflammatory bowel diseases
predisposes to the development of inflammatory bowel disease-associated colorectal …

Cancer comprises a collection of highly proliferative and heterogeneous cells growing within
an adaptive and evolving tumour microenvironment. Cancer survival rates have significantly …

Pancreatitis is a significant clinical problem and the lack of effective therapeutic options
means that treatment is often palliative rather than curative. A deeper understanding of the …

Background & Aims Barrett's esophagus (BE) is a risk factor for esophageal
adenocarcinoma but our understanding of how it evolves is poorly understood. We …

Colorectal cancer (CRC) remains a leading cause of cancer mortality. Here, we define the
colonic epithelial expression of cathelicidin (LL‐37) in CRC. Cathelicidin exerts pleotropic …

Simple Summary New treatment targets are urgently needed for colorectal cancer. Here, we
investigate the role of HMGB1—a multifunctional immune protein—in colorectal cancer. We …

Current methods for analysing immunohistochemistry are labour-intensive and often
confounded by inter-observer variability. Analysis is time consuming when identifying small …

Simple Summary The gut is lined by a single layer of epithelial cells, creating a barrier
between the contents of the gut and the underlying tissue. This barrier also controls …

Background The incidence of oesophageal adenocarcinoma is increasing globally. Barrett's
oesophagus (BO) is a pre-malignant condition with no biomarker to risk stratify those at …