The discovery of an unexpected level of diversity among the killer cell immunoglobulin‐like
receptors has led to a search for their role in human disease. Due to their polymorphism and …

Hepatocellular carcinoma (HCC) arises on the background of chronic liver disease. Despite
the development of effective anti-viral therapeutics HCC is continuing to rise, in part driven …

The key role of natural killer cells in many aspects of the immune response is now being
recognized. The last decade has seen an exponential increase in our understanding of the …

Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United
States, with estimates of 4 million HCV-infected individuals in the United States and 170 …

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory
and activation receptors for major histocompatibility complex class I molecules as a means …

Natural killer (NK) cells have an important role in the control of viral infections, recognizing
virally infected cells through a variety of activating and inhibitory receptors,,. Epidemiological …

That NK cell receptors engage fast-evolving MHC class I ligands suggests that they, too,
evolve rapidly. To test this hypothesis, the structure and class I specificity of chimpanzee KIR …

Chinese translation Background: Hepatitis C virus (HCV) infections occur worldwide and
either spontaneously resolve or persist and markedly increase the person's lifetime risk for …

BACKGROUND & AIMS: Natural killer (NK) cells are essential early after infection, not only
for viral containment but also for timely and efficient induction of adaptive responses. An …

Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer
cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as …