Vitamin D3 seems more appropriate than D2 to sustain adequate levels of 25OHD: a pharmacokinetic approach
B Oliveri, SR Mastaglia, GM Brito, M Seijo… - European journal of …, 2015 - nature.com
European journal of clinical nutrition, 2015•nature.com
Results: Baseline 25OHD values in the D 2 group were lower than those in the D 3 and
placebo groups (P< 0.01). Placebo 25OHD levels never changed. As after the loading dose
both D 2 and D 3 groups had reached similar 25OHD levels, we tested equivalence of the
area under the concentration× time curve (AUC) between d7 and d77. The AUC was 28.6%
higher for D 3 compared with D 2, and both were higher with respect to placebo. At d77, D 2
25OHD levels were higher than those at baseline, but similar to placebo; both were lower …
placebo groups (P< 0.01). Placebo 25OHD levels never changed. As after the loading dose
both D 2 and D 3 groups had reached similar 25OHD levels, we tested equivalence of the
area under the concentration× time curve (AUC) between d7 and d77. The AUC was 28.6%
higher for D 3 compared with D 2, and both were higher with respect to placebo. At d77, D 2
25OHD levels were higher than those at baseline, but similar to placebo; both were lower …
Results:
Baseline 25OHD values in the D 2 group were lower than those in the D 3 and placebo groups (P< 0.01). Placebo 25OHD levels never changed. As after the loading dose both D 2 and D 3 groups had reached similar 25OHD levels, we tested equivalence of the area under the concentration× time curve (AUC) between d7 and d77. The AUC was 28.6% higher for D 3 compared with D 2, and both were higher with respect to placebo. At d77, D 2 25OHD levels were higher than those at baseline, but similar to placebo; both were lower than D 3 (P< 0.04). According to raw data, the elimination half-life of 25OHD was 84 and 111 days under D 2 and D 3 supplementation, respectively; after subtracting the placebo values, the corresponding figures were 33 and 82 days.
Conclusions:
D 2 and D 3 were equally effective in elevating 25OHD levels after a loading dose. In the long term, D 3 seems more appropriate for sustaining 25OHD, which could be relevant for classic and non-classic effects of vitamin D.
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