Abstract
Little information on functional status and well-being is available in patients with functional gastrointestinal disease. We aimed to evaluate whether quality of life is poorer in patients with functional dyspepsia. A consecutive sample of 73 patients with functional dyspepsia completed a validated questionnaire prior to endoscopy. Organic disease controls comprised 658 outpatients attending endoscopy. Quality of life was measured using the validated Medical Outcomes Survey (which assessed physical, role, and social functioning; mental health; health perception; and any bodily pain) and the Brief Symptom Inventory (for current anxiety and depression); additional specific gastrointestinal items were also included. A stepwise logistic regression analysis was used to assess the association between diagnostic group and the quality of life measures, adjusting for potential confounders. Patients who reported more interruptions in their daily activities due to abdominal pain and who had fewer limitations of physical functioning were more likely to have functional dyspepsia (vs other disease,P<0.01). Mental health, social functioning, and health perception also tended to be poorer in functional dyspepsia. We conclude that quality of life may be more impaired in patients with functional dyspepsia than in patients with other conditions, who present for upper endoscopy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ III: Dyspepsia and dyspepsia subgroups: A population-based study. Gastroenterology 102:1259–1268, 1992
Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, Whitehead WE, Janssens J, Funch-Jensen P, Corazziari E, Richter JE, Koch GG: U.S. householder survey of functional gastrointestinal disorders: Prevalence, sociodemography and health impact. Dig Dis Sci 38:1569–1580, 1993
Talley NJ, Colin-Jones DG, Koch KL, Koch M, Nyren O, Stanghellini V: Functional dyspepsia: A classification with guidelines for diagnosis and management. Gastroenterol Int 4:145–160, 1991
Talley NJ, Weaver AL, Tesmer DL, Zinsmeister AR: Lack of discriminant value of dyspepsia subgroups in patients referred for upper endoscopy. Gastroenterology 105:1378–1386, 1993
Guyatt GH, Feeny DH, Patrick DL: Measuring health-related quality of life. Ann Intern Med 118:622–629, 1993
Stewart AL, Greenfield S, Hays RD, Wells K, Rogers WH, Berry SD, McGlynn EA, Ware JE: Functional status and well-being of patients with chronic conditions. Results from the Medical Outcomes Study. JAMA 262:907–913, 1989
Colin-Jones DG (chairman): Management of dyspepsia: Report of a working party. Lancet 1:576–579, 1988
Talley NJ, Weaver AL, Zinsmeister AR: Smoking, alcohol and non-steroidal anti-inflammatory drugs in outpatients with functional dyspepsia and among dyspepsia subgroups. Am J Gastroenterol 89:524–528, 1994
Talley NJ, Phillips SF, Melton LJ III, Wiltgen C, Zinsmeister AR: A patient questionnaire to identify bowel disease. Ann Intern Med 111:671–674, 1989
Talley NJ, Phillips SF, Wiltgen CM, Zinsmeister AR, Melton LJ: Assessment of functional gastrointestinal disease: The bowel disease questionnaire. Mayo Clin Proc 65:1456–1479, 1990
Stewart AL, Hays RD, Ware JE: The MOS short-form general health survey. Med Care 26:724–734, 1988
Wachtel T, Piette J, Mor V, Stein M, Fleishman J, Carpenter C: Quality of life in persons with human immunodeficiency virus infection: Measurement by the medical outcomes study instrument. Ann Intern Med 116:129–137, 1992
Derogatis LR, Melisaratos N: The Brief Symptom Inventory: An introductory report. Psychol Med 13:595–605, 1983
O'Keefe EA, Zinsmeister AR, Talley NJ: Functional bowel disorders negatively impact on quality of life in the elderly. Gastroenterology 102:A495, 1992
Guyatt GH: Measuring quality of life: a review of means of measurement in clinical trials of new medicines. Pharm Med 2:49–60, 1987
Kirschner B, Guyatt GH: A methodologic framework for assessing health indices. J Chron Dis 38:27–36, 1985
Dimenäs E, Glise H, Hallerbäck B, Hernqvist H, Svedlund J, Wiklund I: Quality of life in patients with upper gastrointestinal symptoms. An improved evaluation of treatment regimens? Scand J Gastroenterol 28:681–687, 1993
Abell TL, Cutts TF, Cooper T: Effect of cisapride therapy for severe dyspepsia on gastrointestinal symptoms and quality of life. Scand J Gastroenterol 28(suppl 195):60–64, 1993
Waldron B, Cullen PT, Kumar R, Smith D, Jankowski J, Hopwood D, Sutton D, Kennedy N, Campbell FC: Evidence for hypomotility in non-ulcer dyspepsia: A prospective multifactorial study. Gut 32:246–251, 1991
Inoue M, Sekiguchi T, Harasawa S, Miwa T, Miyoshi A: Dyspepsia and dyspepsia subgroups in Japan: Symptom profiles and experience with cisapride. Scand J Gastroenterol 28(suppl 195):36–39, 1993
Author information
Authors and Affiliations
Additional information
This work was supported in part by grant AG09440 from the National Institutes of Health.
Rights and permissions
About this article
Cite this article
Talley, N.J., Weaver, A.L. & Zinsmeister, A.R. Impact of functional dyspepsia on quality of life. Digest Dis Sci 40, 584–589 (1995). https://doi.org/10.1007/BF02064375
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02064375